JaneL

http://www.genengnews.com/articles/chitem.aspx?aid=2716 __Protein Found that Controls Centriole and Centrosome Copy Number__

Researchers at Cold Spring Harbor Laboratory discovered the protein that controls the copying of the centrosome in human cells and prevents it from being re-duplicated. ORC1, is among the six proteins that comprise the origin recognition complex an assembly that attaches to particular sequences within all DNA in the cell and prepares it for duplication.The scientists revealed that Orc1 additionally controls the number of centrioles in a cell. It seems to accomplish this feat by keeping the pair of centrioles in each centrosome connected to one another. Cells that lacked Orc1 exhibited centrioles that were disengaged from the original. To determine which of the ORC proteins limits centrosome copying, the team used RNAi to block the production of each of the proteins that combine to form ORC in human cells.

The article was interesting. The protein they found can control the copying of the centrosome in human cells and prevents it from being recopied. I learned a lot of information on the protein found and what it does.